Estrogen-based hormone therapy is medicine that can be used as part of your gender transition process. Some of the changes may be permanent while others may be reversible and go away when medication(s) are stopped.
| Effect | Expected Onset | Expected Maximum Effect | Reversibility |
| Breast Growth | 2-6 months | 2-3 years | Permanent |
| Thinning/ Slowed Hair Growth: Face and Body | 6-12 months | >3 years | Reversible |
| Softening of Skin and Decreased Oiliness | 3-6 months | Unknown | Reversible |
| Body Fat Redistribution | 3-6 months | 2-5 years | Reversible |
| Decreased Muscle Mass and Strength | 3-6 months | 1-2 years | Reversible |
| Decreased Sex Drive | 1-3 months | 1-2 years | Reversible |
| Decreased Spontaneous Erections | 1-3 months | 3-6 months | Reversible |
| Less Firm Erections | Variable | Variable | Reversible |
| Decreased Sperm Production/ Reduced Fertility | Variable | Variable | Possibly Permanent |
| Decreased Testicular Volume (By 25-50%) | 3-6 months | 2-3 years | Likely Permanent |
| Cessation of Male Pattern Balding | No Regrowth, Loss stops 1-3 months | 1-2 years | Reversible |