| No. Although it is not uncommon for different medications to affect each another, the prescription antidepressants bupropion (Wellbutrin, Zyban, etc.) and fluoxetine (Prozac, Sarafem, etc.) do not reduce the effectiveness of any contraceptive methods.
There are some types of prescription antidepressants, however, that are affected by hormonal methods. The effects of amitryptiline (Elavil, Endep) and imipramine (Tofranil, Norpramin, and others), may be exaggerated when using hormonal methods, such as the pill, the patch, or the ring.
Because medications often have interactions, it is always important to remember to discuss all the medications you are taking with any clinician you see.
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